Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development
Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy Syndrome (TS), a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted unexpected roles for the L-type voltage-gated Ca2+ channel CaV1.2 in nonexcitable cells. How abnormal Ca2+ influx through CaV1.2 underlies phenotypes such as the accompa...
Alternative Titles
Full title
Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3613930
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3613930
Other Identifiers
ISSN
0021-9738,1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI66903
