RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation
RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation
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Author / Creator
Lee, James T , Shan, Jing , Zhong, Jiayun , Li, Muyang , Zhou, Brenda , Zhou, Amanda , Parsons, Ramon and Gu, Wei
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The PTEN tumor suppressor is a lipid phosphatase that has a central role in regulating the phosphatidylinositol-3- kinase （PI3K） signal transduction cascade. Nevertheless, the mechanism by which the PTEN activity is regulated in cells needs further elucidation. Although previous studies have shown that ubiquitination of PTEN can modulate its stabil...
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Full title
RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3616435
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3616435
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ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/cr.2013.27
