Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Ketan Patel and colleagues report a new mouse model of Fanconi anemia. The authors show that mice deficient in
Btbd12
, the mouse ortholog of
SLX4
(a new Fanconi anemia gene), phenocopy the human disease.
The evolutionarily conserved SLX4 protein, a key regulator of nucleases, is critical for DNA damage response. SLX4 nuclease comple...
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Full title
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3624090
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3624090
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ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/ng.752
