CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling
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Author / Creator
Starokadomskyy, Petro , Gluck, Nathan , Li, Haiying , Chen, Baozhi , Wallis, Mathew , Maine, Gabriel N. , Mao, Xicheng , Zaidi, Iram W. , Hein, Marco Y. , McDonald, Fiona J. , Lenzner, Steffen , Zecha, Agnes , Ropers, Hans-Hilger , Kuss, Andreas W. , McGaughran, Julie , Gecz, Jozef and Burstein, Ezra
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
NF-κB is a master regulator of inflammation and has been implicated in the pathogenesis of immune disorders and cancer. Its regulation involves a variety of steps, including the controlled degradation of inhibitory IκB proteins. In addition, the inactivation of DNA-bound NF-κB is essential for its regulation. This step requires a factor known as co...
Alternative Titles
Full title
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3635737
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3635737
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI66466
