Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors
Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors
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Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Contents
The active sites of 491 human protein kinase domains are highly conserved, which makes the design of selective inhibitors a formidable challenge. We used a structural bioinformatics approach to identify two selectivity filters, a threonine and a cysteine, at defined positions in the active site of p90 ribosomal protein S6 kinase (RSK). A fluorometh...
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Full title
Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3641834
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3641834
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science1108367
