A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into a...
A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Oct4 is considered a master transcription factor for pluripotent cell self-renewal, but its biology remains poorly understood. Here, we investigated the role of Oct4 using the process of induced pluripotency. We found that a defined embryonic stem cell (ESC) level of Oct4 is required for pluripotency entry. However, once pluripotency is established...
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Full title
A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3671976
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3671976
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2742
