Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenil...
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
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Author / Creator
Hinks, Anne , Cobb, Joanna , Marion, Miranda C , Prahalad, Sampath , Sudman, Marc , Bowes, John , Martin, Paul , Comeau, Mary E , Sajuthi, Satria , Andrews, Robert , Brown, Milton , Chen, Wei-Min , Concannon, Patrick , Deloukas, Panos , Edkins, Sarah , Eyre, Stephen , Gaffney, Patrick M , Guthery, Stephen L , Guthridge, Joel M , Hunt, Sarah E , James, Judith A , Keddache, Mehdi , Moser, Kathy L , Nigrovic, Peter A , Onengut-Gumuscu, Suna , Onslow, Mitchell L , Rosé, Carlos D , Rich, Stephen S , Steel, Kathryn J A , Wakeland, Edward K , Wallace, Carol A , Wedderburn, Lucy R , Woo, Patricia , Bohnsack, John F , Haas, Johannes Peter , Glass, David N , Langefeld, Carl D , Thomson, Wendy , Thompson, Susan D , Childhood Arthritis Response to Medication Study (CHARMS) , British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group , German Society for Pediatric Rheumatology (GKJR) , JIA Gene Expression Study , Boston Children's JIA Registry , United Kingdom Juvenile Idiopathic Arthritis Genetics Consortium (UKJIAGC) , NIAMS JIA Genetic Registry , Childhood Arthritis Prospective Study (CAPS) and TREAT Study
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Anne Hinks and colleagues identify 14 new susceptibility loci for juvenile idiopathic arthritis through targeted analyses of genomic regions implicated in immune function. Their study implicates several pathways, including IL-2 signaling, in the pathogenesis of this common childhood autoimmune disease.
We used the Immunochip array to analyze 2,8...
Alternative Titles
Full title
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
Authors, Artists and Contributors
Author / Creator
Cobb, Joanna
Marion, Miranda C
Prahalad, Sampath
Sudman, Marc
Bowes, John
Martin, Paul
Comeau, Mary E
Sajuthi, Satria
Andrews, Robert
Brown, Milton
Chen, Wei-Min
Concannon, Patrick
Deloukas, Panos
Edkins, Sarah
Eyre, Stephen
Gaffney, Patrick M
Guthery, Stephen L
Guthridge, Joel M
Hunt, Sarah E
James, Judith A
Keddache, Mehdi
Moser, Kathy L
Nigrovic, Peter A
Onengut-Gumuscu, Suna
Onslow, Mitchell L
Rosé, Carlos D
Rich, Stephen S
Steel, Kathryn J A
Wakeland, Edward K
Wallace, Carol A
Wedderburn, Lucy R
Woo, Patricia
Bohnsack, John F
Haas, Johannes Peter
Glass, David N
Langefeld, Carl D
Thomson, Wendy
Thompson, Susan D
Childhood Arthritis Response to Medication Study (CHARMS)
British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group
German Society for Pediatric Rheumatology (GKJR)
JIA Gene Expression Study
Boston Children's JIA Registry
United Kingdom Juvenile Idiopathic Arthritis Genetics Consortium (UKJIAGC)
NIAMS JIA Genetic Registry
Childhood Arthritis Prospective Study (CAPS)
TREAT Study
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3673707
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3673707
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2614
