GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and...
GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Somatic hypermutation in B cells is initiated by activation-induced cytidine deaminase-catalyzed C→U deamination at immunoglobulin variable regions. Here we investigate the role of the germinal centre-associated nuclear protein (GANP) in enhancing the access of activation-induced cytidine deaminase (AID) to immunoglobulin variable regions. We show...
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Full title
GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3674236
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3674236
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms2823
