Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Chichester, UK: John Wiley & Sons, Ltd
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Contents
A neuronal F‐box protein FSN‐1 regulates
Caenorhabditis elegans
neuromuscular junction development by negatively regulating DLK‐mediated MAPK signalling. In the present study, we show that attenuation of insulin/IGF signalling also contributes to FSN‐1‐dependent synaptic development and function. The aberrant synapse morphology and synaptic t...
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Full title
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3680742
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3680742
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ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2013.91
