Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Nan Wang and colleagues uncover a new function for HDL that may contribute to its anti-atherosclerotic effects. In the bone marrow, HDL removes cholesterol from megakaryocyte progenitor cells in a process requiring the cholesterol transporter ABCG4, thereby dampening megakaryocyte and platelet production.
Platelets have a key role in atherogenes...
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Full title
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3683965
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3683965
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3150
