Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions
Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The
Igh
locus undergoes a precise order of gene rearrangement during V(D)J recombination. Sen and colleagues show the recruitment of the RAG recombinase is confined to DJH junctions by highly localized epigenetic modifications.
Genes encoding immunoglobulin heavy chains (
Igh
) are assembled by rearrangement of variable (V
H
),...
Alternative Titles
Full title
Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3685187
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3685187
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.2447
