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Crystal Structure of the Calcium Release—Activated Calcium Channel Orai

Crystal Structure of the Calcium Release—Activated Calcium Channel Orai

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3695727

Crystal Structure of the Calcium Release—Activated Calcium Channel Orai

About this item

Full title

Crystal Structure of the Calcium Release—Activated Calcium Channel Orai

Publisher

Washington, DC: American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2012-12, Vol.338 (6112), p.1308-1313

Language

English

Formats

Publication information

Publisher

Washington, DC: American Association for the Advancement of Science

More information

Scope and Contents

Contents

The plasma membrane protein Orai forms the pore of the calcium release—activated calcium (CRAC) channel and generates sustained cytosolic calcium signals when triggered by depletion of calcium from the endoplasmic reticulum. The crystal structure of Orai from Drosophila melanogaster, determined at 3.35 angstrom resolution, reveals that the calcium...

Alternative Titles

Full title

Crystal Structure of the Calcium Release—Activated Calcium Channel Orai

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3695727

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3695727

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.1228757