Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells
Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Tumor-initiating stem-like cells (TICs) are resistant to chemotherapy and associated with hepatocellular carcinoma (HCC) caused by HCV and/or alcohol-related chronic liver injury. Using HCV Tg mouse models and patients with HCC, we isolated CD133(+) TICs and identified the pluripotency marker NANOG as a direct target of TLR4, which drives the tumor...
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Full title
Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3696549
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3696549
Other Identifiers
ISSN
0021-9738,1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI65859
