Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans
Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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The adenovirus type 5 (Ad5)-based vaccine developed by Merck failed to either prevent HIV-1 infection or suppress viral load in subsequently infected subjects in the STEP human Phase 2b efficacy trial. Analogous vaccines had previously also failed in the simian immunodeficiency virus (SIV) challenge–rhesus macaque model. In contrast, vaccine protec...
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Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3697853
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3697853
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.f.1759
