ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epilep...
ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice
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Author / Creator
Tiveron, C , Fasulo, L , Capsoni, S , Malerba, F , Marinelli, S , Paoletti, F , Piccinin, S , Scardigli, R , Amato, G , Brandi, R , Capelli, P , D'Aguanno, S , Florenzano, F , La Regina, F , Lecci, A , Manca, A , Meli, G , Pistillo, L , Berretta, N , Nisticò, R , Pavone, F and Cattaneo, A
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
ProNGF, the precursor of mature nerve growth factor (NGF), is the most abundant form of NGF in the brain. ProNGF and mature NGF differ significantly in their receptor interaction properties and in their bioactivity. ProNGF increases markedly in the cortex of Alzheimer’s disease (AD) brains and proNGF\NGF imbalance has been postulated to play a role...
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Full title
ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3705592
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3705592
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ISSN
1350-9047,1476-5403
E-ISSN
1476-5403
DOI
10.1038/cdd.2013.22
