A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease
A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Mutations in the
park2
gene, encoding the RING-inBetweenRING-RING E3 ubiquitin ligase parkin, cause 50% of autosomal recessive juvenile Parkinsonism cases. More than 70 known pathogenic mutations occur throughout parkin, many of which cluster in the inhibitory amino-terminal ubiquitin-like domain, and the carboxy-terminal RING2 domain that is...
Alternative Titles
Full title
A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3709501
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3709501
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms2983
