Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription prof...
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
About this item
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Publisher
England: John Wiley & Sons, Inc
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Language
English
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Publisher
England: John Wiley & Sons, Inc
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Summary
Caloric restriction (CR) and down‐regulation of the insulin/IGF pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by CR in humans. Here, we report that long‐term CR in humans inhibits the IGF‐1/insulin pathway in skeletal muscle, a ke...
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Full title
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3714316
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3714316
Other Identifiers
ISSN
1474-9718
E-ISSN
1474-9726
DOI
10.1111/acel.12088
