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Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3715864

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

About this item

Full title

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

Publisher

Chichester, UK: John Wiley & Sons, Ltd

Journal title

The EMBO journal, 2013-07, Vol.32 (14), p.2015-2028

Language

English

Formats

Publication information

Publisher

Chichester, UK: John Wiley & Sons, Ltd

More information

Scope and Contents

Contents

The protease β‐secretase 1 (Bace1) was identified through its critical role in production of amyloid‐β peptides (Aβ), the major component of amyloid plaques in Alzheimer's disease. Bace1 is considered a promising target for the treatment of this pathology, but processes additional substrates, among them Neuregulin‐1 (Nrg1). Our biochemical analysis...

Alternative Titles

Full title

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3715864

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3715864

Other Identifiers

ISSN

0261-4189

E-ISSN

1460-2075

DOI

10.1038/emboj.2013.146

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