The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experiment...
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis
About this item
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Author / Creator
Schmidt, Eric P , Yang, Yimu , Janssen, William J , Gandjeva, Aneta , Perez, Mario J , Barthel, Lea , Zemans, Rachel L , Bowman, Joel C , Koyanagi, Dan E , Yunt, Zulma X , Smith, Lynelle P , Cheng, Sara S , Overdier, Katherine H , Thompson, Kathy R , Geraci, Mark W , Douglas, Ivor S , Pearse, David B and Tuder, Rubin M
Publisher
New York: Nature Publishing Group US
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Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The glycocalyx is a layer of proteoglycans and complex carbohydrates that lines the endothelial cell surface in blood vessels. Schmidt
et al
. show that in mouse models of sepsis, lung inflammation and injury depend on glycocalyx degradation, which increases neutrophil access to endothelial adhesion molecules. The authors also provide data in...
Alternative Titles
Full title
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3723751
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3723751
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2843
