Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction
Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The non-haem-iron-dependent enzyme HppE catalyses the final step in the biosynthesis of fosfomycin, a broad-spectrum, clinically useful antibiotic; here it is shown that HppE can also catalyse a 1,2-phosphono-migration reaction, previously undocumented for any enzyme.
Enzyme catalysis of a novel phosphono migration
The last step in the biosyn...
Alternative Titles
Full title
Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3725809
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3725809
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11998
