Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer disease (AD). Guojun Bu and colleagues describe the pathogenic links between Apo-E4 and neurodegeneration, including amyloid-β-dependent mechanisms and impairment of neurovascular function. The authors suggest potential strategies to target Apo-E, w...
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Full title
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3726719
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3726719
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ISSN
1759-4758
E-ISSN
1759-4766
DOI
10.1038/nrneurol.2012.263
