A two-step mechanism for TRF2-mediated chromosome-end protection
A two-step mechanism for TRF2-mediated chromosome-end protection
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The telomere-biding protein TRF2 is shown to protect telomeres from activating the DNA-damage response through two mechanisms: preventing the activation ATM kinase through its dimerization domain, in addition to independently suppressing signalling events occurring downstream of ATM.
Telomere protection from damaging 'repair'
The telomere-bin...
Alternative Titles
Full title
A two-step mechanism for TRF2-mediated chromosome-end protection
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3733551
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3733551
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11873
