Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function
Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function
About this item
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Publisher
Boston: Boston : Springer US
Journal title
Language
English
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Publisher
Boston: Boston : Springer US
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Scope and Contents
Contents
Cyclooxygenase-2 (COX-2) is associated with aggressive breast cancers. The COX-2 product prostaglandin E₂ (PGE₂) acts through four G-protein-coupled receptors designated EP1-4. Malignant and immortalized normal mammary epithelial cell lines express all four EP. The EP4 antagonist AH23848 reduced the ability of tumor cells to colonize the lungs or t...
Alternative Titles
Full title
Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3738188
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3738188
Other Identifiers
ISSN
0167-6806
E-ISSN
1573-7217
DOI
10.1007/s10549-008-0180-5
