Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Neurons within the CA3 region of the hippocampus are relatively resistant to cell death after ischemia. Alastair M. Buchan and his colleagues demonstrate that the product of the
TSC1
gene, hamartin, is upregulated in CA3 neurons in response to ischemia. Hamartin promotes survival by inhibiting mTORC1 and increasing autophagic flux in neurons....
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Full title
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3744134
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3744134
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3097
