Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron...
Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study
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Publisher
Berlin/Heidelberg: Springer-Verlag
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Language
English
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Publisher
Berlin/Heidelberg: Springer-Verlag
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rTg4510 transgenic (TG) mice overexpress mutant (P301L) human tau protein. We have compared the dorsal premotor cortex of TG mice versus non-transgenic (NT) mice at 4, 9, and 13 months of age, using light (LM) and electron microscopy (EM). LM assessment shows that cortical thickness in TG mice is reduced by almost 50% from 4 to 13 months of age, wh...
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Full title
Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3748379
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3748379
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ISSN
1863-2653
E-ISSN
1863-2661,0340-2061
DOI
10.1007/s00429-010-0295-4
