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Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3754253

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

About this item

Full title

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2013-09, Vol.123 (9), p.3815-3828

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein-associated (HDL-associated) proteins mechanistically linked to inflammation, oxidant stress, and atherosclerosis. MPO is a source of ROS during inflammation and can oxidize apolipoprotein A1 (APOA1) of HDL, impairing its atheroprotective functions. In contrast, PON1 fosters...

Alternative Titles

Full title

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3754253

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3754253

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI67478

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