Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy
Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy
About this item
Full title
Author / Creator
Johnson, Leisa , Huseni, Mahrukh , Smyczek, Tanya , Lima, Anthony , Yeung, Stacey , Cheng, Jason H. , Molina, Rafael , Kan, David , De Mazière, Ann , Klumperman, Judith , Kasman, Ian , Zhang, Yin , Dennis, Mark S. , Eastham-Anderson, Jeffrey , Jubb, Adrian M. , Hwang, Olivia , Desai, Rupal , Schmidt, Maike , Nannini, Michelle A. , Barck, Kai H. , Carano, Richard A.D. , Forrest, William F. , Song, Qinghua , Chen, Daniel S. , Naumovski, Louie , Singh, Mallika , Ye, Weilan and Hegde, Priti S.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Many oncology drugs are administered at their maximally tolerated dose without the knowledge of their optimal efficacious dose range. In this study, we describe a multifaceted approach that integrated preclinical and clinical data to identify the optimal dose for an antiangiogenesis agent, anti-EGFL7. EGFL7 is an extracellular matrix-associated pro...
Alternative Titles
Full title
Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy
Authors, Artists and Contributors
Author / Creator
Huseni, Mahrukh
Smyczek, Tanya
Lima, Anthony
Yeung, Stacey
Cheng, Jason H.
Molina, Rafael
Kan, David
De Mazière, Ann
Klumperman, Judith
Kasman, Ian
Zhang, Yin
Dennis, Mark S.
Eastham-Anderson, Jeffrey
Jubb, Adrian M.
Hwang, Olivia
Desai, Rupal
Schmidt, Maike
Nannini, Michelle A.
Barck, Kai H.
Carano, Richard A.D.
Forrest, William F.
Song, Qinghua
Chen, Daniel S.
Naumovski, Louie
Singh, Mallika
Ye, Weilan
Hegde, Priti S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3754254
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3754254
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI67892
