Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Contents
The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic...
Alternative Titles
Full title
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3764501
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3764501
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1108750
