Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
About this item
Full title
Author / Creator
Maurano, Matthew T. , Humbert, Richard , Rynes, Eric , Thurman, Robert E. , Haugen, Eric , Wang, Hao , Reynolds, Alex P. , Sandstrom, Richard , Qu, Hongzhu , Brody, Jennifer , Shafer, Anthony , Neri, Fidencio , Lee, Kristen , Kutyavin, Tanya , Stehling-Sun, Sandra , Johnson, Audra K. , Canfield, Theresa K. , Giste, Erika , Diegel, Morgan , Bates, Daniel , Hansen, R. Scott , Neph, Shane , Sabo, Peter J. , Heimfeld, Shelly , Raubitschek, Antony , Ziegler, Steven , Cotsapas, Chris , Sotoodehnia, Nona , Glass, Ian , Sunyaev, Shamil R. , Kaul, Rajinder and Stamatoyannopoulos, John A.
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Genome-wide association studies have identified many noncoding variants associated with common diseases and traits. We show that these variants are concentrated in regulatory DNA marked by deoxyribonuclease I (DNase I) hypersensitive sites (DHSs). Eighty-eight percent of such DHSs are active during fetal development and are enriched in variants ass...
Alternative Titles
Full title
Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
Authors, Artists and Contributors
Author / Creator
Humbert, Richard
Rynes, Eric
Thurman, Robert E.
Haugen, Eric
Wang, Hao
Reynolds, Alex P.
Sandstrom, Richard
Qu, Hongzhu
Brody, Jennifer
Shafer, Anthony
Neri, Fidencio
Lee, Kristen
Kutyavin, Tanya
Stehling-Sun, Sandra
Johnson, Audra K.
Canfield, Theresa K.
Giste, Erika
Diegel, Morgan
Bates, Daniel
Hansen, R. Scott
Neph, Shane
Sabo, Peter J.
Heimfeld, Shelly
Raubitschek, Antony
Ziegler, Steven
Cotsapas, Chris
Sotoodehnia, Nona
Glass, Ian
Sunyaev, Shamil R.
Kaul, Rajinder
Stamatoyannopoulos, John A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3771521
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3771521
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1222794
