P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escit...
P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents
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Basingstoke: Nature Publishing Group
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Language
English
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Publisher
Basingstoke: Nature Publishing Group
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Contents
Despite the clinical prevalence of the antidepressant escitalopram, over 30% of escitalopram-treated patients fail to respond to treatment. Recent gene association studies have highlighted a potential link between the drug efflux transporter P-glycoprotein (P-gp) and response to escitalopram. The present studies investigated pharmacokinetic and pha...
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Full title
P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3773671
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3773671
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ISSN
0893-133X
E-ISSN
1740-634X
DOI
10.1038/npp.2013.120
