Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System
Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System
About this item
Full title
Author / Creator
Kishimoto, Takashi Kei , Viswanathan, Karthik , Ganguly, Tanmoy , Elankumaran, Subbiah , Smith, Sean , Pelzer, Kevin , Lansing, Jonathan C , Sriranganathan, Nammalwar , Zhao, Ganlin , Galcheva-Gargova, Zoya , Al-Hakim, Ali , Bailey, Gregory Scott , Fraser, Blair , Roy, Sucharita , Rogers-Cotrone, Thomas , Buhse, Lucinda , Whary, Mark , Fox, James , Nasr, Moheb , Dal Pan, Gerald J , Shriver, Zachary , Langer, Robert S , Venkataraman, Ganesh , Austen, K. Frank , Woodcock, Janet and Sasisekharan, Ram
Publisher
Boston, MA: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
Boston, MA: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
Recently the heparin supply in 12 countries was found to be contaminated with a substance that caused hypotension and, in some cases, death. The contaminant has been identified as oversulfated chondroitin sulfate (OSCS). This study shows that OSCS can activate the kinin–kallikrein pathway and the complement system, which can result in the clinical...
Alternative Titles
Full title
Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System
Authors, Artists and Contributors
Author / Creator
Viswanathan, Karthik
Ganguly, Tanmoy
Elankumaran, Subbiah
Smith, Sean
Pelzer, Kevin
Lansing, Jonathan C
Sriranganathan, Nammalwar
Zhao, Ganlin
Galcheva-Gargova, Zoya
Al-Hakim, Ali
Bailey, Gregory Scott
Fraser, Blair
Roy, Sucharita
Rogers-Cotrone, Thomas
Buhse, Lucinda
Whary, Mark
Fox, James
Nasr, Moheb
Dal Pan, Gerald J
Shriver, Zachary
Langer, Robert S
Venkataraman, Ganesh
Austen, K. Frank
Woodcock, Janet
Sasisekharan, Ram
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3778681
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3778681
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa0803200
