Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation
Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation
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Publisher
Alexandria, VA: American Diabetes Association
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Language
English
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Publisher
Alexandria, VA: American Diabetes Association
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Contents
Sirt3 is an NAD(+)-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression is decreased in skeletal muscle resulting in increased mitochondrial protein acetylation. Deletion of Sirt3 led to impaired glucose oxidation in muscle, which was associated with decreased pyr...
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Full title
Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3781465
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3781465
Other Identifiers
ISSN
0012-1797
E-ISSN
1939-327X
DOI
10.2337/db12-1650
