PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
About this item
Full title
Author / Creator
Neviani, Paolo , Harb, Jason G. , Oaks, Joshua J. , Santhanam, Ramasamy , Walker, Christopher J. , Ellis, Justin J. , Ferenchak, Gregory , Dorrance, Adrienne M. , Paisie, Carolyn A. , Eiring, Anna M. , Ma, Yihui , Mao, Hsiaoyin C. , Zhang, Bin , Wunderlich, Mark , May, Philippa C. , Sun, Chaode , Saddoughi, Sahar A. , Bielawski, Jacek , Blum, William , Klisovic, Rebecca B. , Solt, Janelle A. , Byrd, John C. , Volinia, Stefano , Cortes, Jorge , Huettner, Claudia S. , Koschmieder, Steffen , Holyoake, Tessa L. , Devine, Steven , Caligiuri, Michael A. , Croce, Carlo M. , Garzon, Ramiro , Ogretmen, Besim , Arlinghaus, Ralph B. , Chen, Ching-Shih , Bittman, Robert , Hokland, Peter , Roy, Denis-Claude , Milojkovic, Dragana , Apperley, Jane , Goldman, John M. , Reid, Alistair , Mulloy, James C. , Bhatia, Ravi , Marcucci, Guido and Perrotti, Danilo
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
The success of tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML) depends on the requirement for BCR-ABL1 kinase activity in CML progenitors. However, CML quiescent HSCs are TKI resistant and represent a BCR-ABL1 kinase-independent disease reservoir. Here we have shown that persistence of leukemic HSCs in BM requires inhib...
Alternative Titles
Full title
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
Authors, Artists and Contributors
Author / Creator
Harb, Jason G.
Oaks, Joshua J.
Santhanam, Ramasamy
Walker, Christopher J.
Ellis, Justin J.
Ferenchak, Gregory
Dorrance, Adrienne M.
Paisie, Carolyn A.
Eiring, Anna M.
Ma, Yihui
Mao, Hsiaoyin C.
Zhang, Bin
Wunderlich, Mark
May, Philippa C.
Sun, Chaode
Saddoughi, Sahar A.
Bielawski, Jacek
Blum, William
Klisovic, Rebecca B.
Solt, Janelle A.
Byrd, John C.
Volinia, Stefano
Cortes, Jorge
Huettner, Claudia S.
Koschmieder, Steffen
Holyoake, Tessa L.
Devine, Steven
Caligiuri, Michael A.
Croce, Carlo M.
Garzon, Ramiro
Ogretmen, Besim
Arlinghaus, Ralph B.
Chen, Ching-Shih
Bittman, Robert
Hokland, Peter
Roy, Denis-Claude
Milojkovic, Dragana
Apperley, Jane
Goldman, John M.
Reid, Alistair
Mulloy, James C.
Bhatia, Ravi
Marcucci, Guido
Perrotti, Danilo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3784537
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3784537
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI68951
