Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
About this item
Full title
Author / Creator
Blair, Laura J. , Nordhues, Bryce A. , Hill, Shannon E. , Scaglione, K. Matthew , O’Leary, John C. , Fontaine, Sarah N. , Breydo, Leonid , Zhang, Bo , Li, Pengfei , Wang, Li , Cotman, Carl , Paulson, Henry L. , Muschol, Martin , Uversky, Vladimir N. , Klengel, Torsten , Binder, Elisabeth B. , Kayed, Rakez , Golde, Todd E. , Berchtold, Nicole and Dickey, Chad A.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Aggregation of tau protein in the brain is associated with a class of neurodegenerative diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51, encoded by FKBP5) forms a mature chaperone complex with Hsp90 that prevents tau degradation. In this study, we have shown that tau levels are reduced throughout the brains of Fkbp5-/- mice. Rec...
Alternative Titles
Full title
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
Authors, Artists and Contributors
Author / Creator
Nordhues, Bryce A.
Hill, Shannon E.
Scaglione, K. Matthew
O’Leary, John C.
Fontaine, Sarah N.
Breydo, Leonid
Zhang, Bo
Li, Pengfei
Wang, Li
Cotman, Carl
Paulson, Henry L.
Muschol, Martin
Uversky, Vladimir N.
Klengel, Torsten
Binder, Elisabeth B.
Kayed, Rakez
Golde, Todd E.
Berchtold, Nicole
Dickey, Chad A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3784538
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3784538
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI69003
