A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resist...
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
About this item
Full title
Author / Creator
Lunardi, Andrea , Ala, Ugo , Epping, Mirjam T , Salmena, Leonardo , Clohessy, John G , Webster, Kaitlyn A , Wang, Guocan , Mazzucchelli, Roberta , Bianconi, Maristella , Stack, Edward C , Lis, Rosina , Patnaik, Akash , Cantley, Lewis C , Bubley, Glenn , Cordon-Cardo, Carlos , Gerald, William L , Montironi, Rodolfo , Signoretti, Sabina , Loda, Massimo , Nardella, Caterina and Pandolfi, Pier Paolo
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Pier Paolo Pandolfi and colleagues report that compound loss of
Pten
with
Zbtb7a
or
Trp53
leads to
de novo
resistance to androgen deprivation therapy in prostate cancer. Integrative analysis of mouse and human data in a co-clinical approach identified XIAP and SRD5A1 inhibitors as potential therapies for castration-resistant...
Alternative Titles
Full title
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
Authors, Artists and Contributors
Author / Creator
Ala, Ugo
Epping, Mirjam T
Salmena, Leonardo
Clohessy, John G
Webster, Kaitlyn A
Wang, Guocan
Mazzucchelli, Roberta
Bianconi, Maristella
Stack, Edward C
Lis, Rosina
Patnaik, Akash
Cantley, Lewis C
Bubley, Glenn
Cordon-Cardo, Carlos
Gerald, William L
Montironi, Rodolfo
Signoretti, Sabina
Loda, Massimo
Nardella, Caterina
Pandolfi, Pier Paolo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3787876
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3787876
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2650
