The ribosome triggers the stringent response by RelA via a highly distorted tRNA
The ribosome triggers the stringent response by RelA via a highly distorted tRNA
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
The bacterial stringent response links nutrient starvation with the transcriptional control of genes. This process is initiated by the stringent factor RelA, which senses the presence of deacylated tRNA in the ribosome as a symptom of amino‐acid starvation to synthesize the alarmone (p)ppGpp. Here we report a cryo‐EM study of RelA bound to ribosome...
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Full title
The ribosome triggers the stringent response by RelA via a highly distorted tRNA
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3790049
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3790049
Other Identifiers
ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/embor.2013.106
