A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
About this item
Full title
Author / Creator
Wei, Kevin , Piecewicz, Stephanie M , McGinnis, Lisa M , Taniguchi, Cullen M , Wiegand, Stanley J , Anderson, Keith , Chan, Carol W-M , Mulligan, Kimberly X , Kuo, David , Yuan, Jenny , Vallon, Mario , Morton, Lori C , Lefai, Etienne , Simon, M Celeste , Maher, Jacquelyn J , Mithieux, Gilles , Rajas, Fabienne , Annes, Justin P , McGuinness, Owen P , Thurston, Gavin , Giaccia, Amato J and Kuo, Calvin J
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
In two separate studies, Amato Giaccia and Calvin Kuo and colleagues show that targeting of hypoxia-inducible factor-2α to increase its expression results in elevation of a key downstream effector of insulin signaling and thus improved insulin sensitivity in a mouse model of type 2 diabetes.
Insulin initiates diverse hepatic metabolic responses,...
Alternative Titles
Full title
A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
Authors, Artists and Contributors
Author / Creator
Piecewicz, Stephanie M
McGinnis, Lisa M
Taniguchi, Cullen M
Wiegand, Stanley J
Anderson, Keith
Chan, Carol W-M
Mulligan, Kimberly X
Kuo, David
Yuan, Jenny
Vallon, Mario
Morton, Lori C
Lefai, Etienne
Simon, M Celeste
Maher, Jacquelyn J
Mithieux, Gilles
Rajas, Fabienne
Annes, Justin P
McGuinness, Owen P
Thurston, Gavin
Giaccia, Amato J
Kuo, Calvin J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3795838
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3795838
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X,1744-7933
DOI
10.1038/nm.3295
