A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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The cancer-associated D2723H mutation causes mislocalization of BRCA2 to the cytoplasm. New work shows that this mutation disrupts the interaction of BRCA2 with DSS1, unmasking a BRCA2 nuclear export signal within the DSS1 binding domain. This impairs nuclear retention of BRCA2 and, consequently, RAD51, suggesting that the intracellular localizatio...
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A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3796201
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3796201
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ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/nsmb.2666
