Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The anaphase-promoting complex (APC) is the crucial ubiquitin ligase targeting the regulatory machinery of the cell cycle. Emi1, a major modulator of APC activity, is thought to act competitively as a pseudosubstrate. We show that the modulation of APC activity is more subtle: Emi1 inhibits ubiquitylation at both substrate binding and separately at...
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Full title
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3812805
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3812805
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2755
