Cytomegalovirus Vectors Violate CD8⁺ T Cell Epitope Recognition Paradigms
Cytomegalovirus Vectors Violate CD8⁺ T Cell Epitope Recognition Paradigms
About this item
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Author / Creator
Hansen, Scott G. , Sacha, Jonah B. , Hughes, Colette M. , Ford, Julia C. , Burwitz, Benjamin J. , Scholz, Isabel , Gilbride, Roxanne M. , Lewis, Matthew S. , Gilliam, Awbrey N. , Ventura, Abigail B. , Malouli, Daniel , Xu, Guangwu , Richards, Rebecca , Whizin, Nathan , Reed, Jason S. , Hammond, Katherine B. , Fischer, Miranda , Turner, John M. , Legasse, Alfred W. , Axthelm, Michael K. , Edlefsen, Paul T. , Nelson, Jay A. , Lifson, Jeffrey D. , Früh, Klaus and Picker, Louis J.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
CD8(+) T cell responses focus on a small fraction of pathogen- or vaccine-encoded peptides, and for some pathogens, these restricted recognition hierarchies limit the effectiveness of antipathogen immunity. We found that simian immunodeficiency virus (SIV) protein-expressing rhesus cytomegalovirus (RhCMV) vectors elicit SIV-specific CD8(+) T cells...
Alternative Titles
Full title
Cytomegalovirus Vectors Violate CD8⁺ T Cell Epitope Recognition Paradigms
Authors, Artists and Contributors
Author / Creator
Sacha, Jonah B.
Hughes, Colette M.
Ford, Julia C.
Burwitz, Benjamin J.
Scholz, Isabel
Gilbride, Roxanne M.
Lewis, Matthew S.
Gilliam, Awbrey N.
Ventura, Abigail B.
Malouli, Daniel
Xu, Guangwu
Richards, Rebecca
Whizin, Nathan
Reed, Jason S.
Hammond, Katherine B.
Fischer, Miranda
Turner, John M.
Legasse, Alfred W.
Axthelm, Michael K.
Edlefsen, Paul T.
Nelson, Jay A.
Lifson, Jeffrey D.
Früh, Klaus
Picker, Louis J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3816976
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3816976
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.1237874
