Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model
Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Using an
in vivo
cycling strategy, we selected metastatic cancer cells from the lymph nodes (LN) of mice bearing orthotopic DU145 human prostate tumors. Repeated rounds of metastatic selection (LN1–LN4) progressively increased the epithelial phenotype, resulting in a new model of tumor cell mesenchymal-epithelial transition (MET). DU145-LN4 s...
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Full title
Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3818652
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3818652
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep03151
