Structure of the CCR5 Chemokine Receptor—HIV Entry Inhibitor Maraviroc Complex
Structure of the CCR5 Chemokine Receptor—HIV Entry Inhibitor Maraviroc Complex
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Author / Creator
Tan, Qiuxiang , Zhu, Ya , Li, Jian , Chen, Zhuxi , Han, Gye Won , Kufareva, Irina , Li, Tingting , Ma, Limin , Fenalti, Gustavo , Li, Jing , Zhang, Wenru , Xie, Xin , Yang, Huaiyu , Jiang, Hualiang , Cherezov, Vadim , Liu, Hong , Stevens, Raymond C. , Zhao, Qiang , Wu, Beili and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the 2.7 angstrom-resolution crystal structure of human CCR5 bound to the marketed HIV drug maraviroc. The structure reveals a ligand-binding site that is distinct from the proposed major recognition sites for chemokines and the viral glycoprotein gp120, providin...
Alternative Titles
Full title
Structure of the CCR5 Chemokine Receptor—HIV Entry Inhibitor Maraviroc Complex
Authors, Artists and Contributors
Author / Creator
Zhu, Ya
Li, Jian
Chen, Zhuxi
Han, Gye Won
Kufareva, Irina
Li, Tingting
Ma, Limin
Fenalti, Gustavo
Li, Jing
Zhang, Wenru
Xie, Xin
Yang, Huaiyu
Jiang, Hualiang
Cherezov, Vadim
Liu, Hong
Stevens, Raymond C.
Zhao, Qiang
Wu, Beili
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3819204
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3819204
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1241475
