Reduced ligand affinity leads to an impaired function of the adenosine A2A receptor of human granulo...
Reduced ligand affinity leads to an impaired function of the adenosine A2A receptor of human granulocytes in sepsis
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Author / Creator
Publisher
Oxford, UK: Blackwell Publishing Ltd
Journal title
Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Scope and Contents
Contents
The enhanced release of reactive oxygen species by excessively activated polymorphonuclear leucocytes (PMN) is a key step in the pathogenesis of sepsis. Potent action of adenosine in inhibiting cytotoxic PMN functions has been documented. Recent data, however provide evidence that in sepsis a diminished capability of adenosine to inhibit the genera...
Alternative Titles
Full title
Reduced ligand affinity leads to an impaired function of the adenosine A2A receptor of human granulocytes in sepsis
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3823413
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3823413
Other Identifiers
ISSN
1582-1838
E-ISSN
1582-4934
DOI
10.1111/j.1582-4934.2008.00530.x
