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PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White...

PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3837041

PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders

About this item

Full title

PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders

Publisher

Alexandria, VA: American Diabetes Association

Journal title

Diabetes (New York, N.Y.), 2013-12, Vol.62 (12), p.4122-4131

Language

English

Formats

Publication information

Publisher

Alexandria, VA: American Diabetes Association

More information

Scope and Contents

Contents

Erythropoietin (EPO) has shown beneficial effects in the regulation of obesity and metabolic syndrome; however, the detailed mechanism is still largely unknown. Here, we created mice with adipocyte-specific deletion of EPO receptor. These mice exhibited obesity and decreased glucose tolerance and insulin sensitivity, especially when fed a high-fat...

Alternative Titles

Full title

PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3837041

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3837041

Other Identifiers

ISSN

0012-1797

E-ISSN

1939-327X

DOI

10.2337/db13-0518

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