A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation
A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation
About this item
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Author / Creator
Ojo, Kayode K. , Eastman, Richard T. , Vidadala, RamaSubbaRao , Zhang, Zhongsheng , Rivas, Kasey L. , Choi, Ryan , Lutz, Justin D. , Reid, Molly C. , Fox, Anna M. W. , Hulverson, Matthew A. , Kennedy, Mark , Isoherranen, Nina , Kim, Laura M. , Comess, Kenneth M. , Kempf, Dale J. , Verlinde, Christophe L. M. J. , Su, Xin-zhuan , Kappe, Stefan H. I. , Maly, Dustin J. , Fan, Erkang and Van Voorhis, Wesley C.
Publisher
Oxford: Oxford University Press
Journal title
Language
English
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Publication information
Publisher
Oxford: Oxford University Press
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More information
Scope and Contents
Contents
Malaria parasites are transmitted by mosquitoes, and blocking parasite transmission is critical in reducing or eliminating malaria in endemic regions. Here, we report the pharmacological characterization of a new class of malaria transmission-blocking compounds that acts via the inhibition of Plasmodia CDPK4 enzyme. We demonstrate that these compou...
Alternative Titles
Full title
A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation
Authors, Artists and Contributors
Author / Creator
Eastman, Richard T.
Vidadala, RamaSubbaRao
Zhang, Zhongsheng
Rivas, Kasey L.
Choi, Ryan
Lutz, Justin D.
Reid, Molly C.
Fox, Anna M. W.
Hulverson, Matthew A.
Kennedy, Mark
Isoherranen, Nina
Kim, Laura M.
Comess, Kenneth M.
Kempf, Dale J.
Verlinde, Christophe L. M. J.
Su, Xin-zhuan
Kappe, Stefan H. I.
Maly, Dustin J.
Fan, Erkang
Van Voorhis, Wesley C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3873787
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3873787
Other Identifiers
ISSN
0022-1899,1537-6613
E-ISSN
1537-6613
DOI
10.1093/infdis/jit522
