Regulation of HIF-1α activity by overexpression of thioredoxin is independent of thioredoxin reducta...
Regulation of HIF-1α activity by overexpression of thioredoxin is independent of thioredoxin reductase status
About this item
Full title
Author / Creator
Naranjo-Suarez, S., National Institutes of Health, Bethesda, USA , Carlson, B.A., National Institutes of Health, Bethesda, USA , Tobe, R., National Institutes of Health, Bethesda, USA , Yoo, M.H., National Institutes of Health, Bethesda, USA , Tsuji, P., Towson University, Towson, USA , Gladyshev, V.N., Brigham and Women’s Hospital and Harvard Medical School, Boston, USA and Hatfield, D.L., National Institutes of Health, Bethesda, USA
Publisher
Dordrecht: Springer Netherlands
Journal title
Language
English
Formats
Publication information
Publisher
Dordrecht: Springer Netherlands
Subjects
More information
Scope and Contents
Contents
Under hypoxic conditions, cells activate a transcriptional response mainly driven by hypoxia-inducible factors (HIFs). HIF-1α stabilization and activity are known to be regulated by thioredoxin 1 (Txn1), but how the thioredoxin system regulates the hypoxic response is unknown. By examining the effects of Txn1 overexpression on HIF-1α function in He...
Alternative Titles
Full title
Regulation of HIF-1α activity by overexpression of thioredoxin is independent of thioredoxin reductase status
Authors, Artists and Contributors
Author / Creator
Carlson, B.A., National Institutes of Health, Bethesda, USA
Tobe, R., National Institutes of Health, Bethesda, USA
Yoo, M.H., National Institutes of Health, Bethesda, USA
Tsuji, P., Towson University, Towson, USA
Gladyshev, V.N., Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
Hatfield, D.L., National Institutes of Health, Bethesda, USA
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3887957
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3887957
Other Identifiers
ISSN
1016-8478
E-ISSN
0219-1032
DOI
10.1007/s10059-013-0121-y
