Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Monitoring the half-life of mutant huntingtin protein reveals how specific neurons are more susceptible to its toxic effects and to Huntington's disease.
In polyglutamine (polyQ) diseases, only certain neurons die, despite widespread expression of the offending protein. PolyQ expansion may induce neurodegeneration by impairing proteostasis, but...
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Full title
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3900497
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3900497
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1308
