Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
The endothelial Tie1 receptor is ligand-less, but interacts with the Tie2 receptor for angiopoietins (Angpt). Angpt2 is expressed in tumor blood vessels, and its blockade inhibits tumor angiogenesis. Here we found that Tie1 deletion from the endothelium of adult mice inhibits tumor angiogenesis and growth by decreasing endothelial cell survival in...
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Full title
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3904604
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3904604
Other Identifiers
ISSN
0021-9738,1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI68897
