Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineag...
Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage
About this item
Full title
Author / Creator
Murchison, Elizabeth P , Wedge, David C , Alexandrov, Ludmil B , Fu, Beiyuan , Martincorena, Inigo , Ning, Zemin , Tubio, Jose M C , Werner, Emma I , Allen, Jan , De Nardi, Andrigo Barboza , Donelan, Edward M , Marino, Gabriele , Fassati, Ariberto , Campbell, Peter J , Yang, Fengtang , Burt, Austin , Weiss, Robin A and Stratton, Michael R
Publisher
United States
Journal title
Language
English
Formats
Publication information
Publisher
United States
Subjects
More information
Scope and Contents
Contents
Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two CTVT tumors and found that CTVT has acquired 1.9 million somatic substitution mutations and bears evidence of exposure to ultraviolet light. CTVT is remarkably stable an...
Alternative Titles
Full title
Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage
Authors, Artists and Contributors
Author / Creator
Wedge, David C
Alexandrov, Ludmil B
Fu, Beiyuan
Martincorena, Inigo
Ning, Zemin
Tubio, Jose M C
Werner, Emma I
Allen, Jan
De Nardi, Andrigo Barboza
Donelan, Edward M
Marino, Gabriele
Fassati, Ariberto
Campbell, Peter J
Yang, Fengtang
Burt, Austin
Weiss, Robin A
Stratton, Michael R
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3918581
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3918581
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1247167
