ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response
ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response
About this item
Full title
Author / Creator
Pawlikowska, P , Leray, I , de Laval, B , Guihard, S , Kumar, R , Rosselli, F and Porteu, F
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The early-response gene product IEX-1 (also known as IER3) was recently found to interact with the anti-apoptotic Bcl-2 family member, myeloid cell leukemia-1 (Mcl-1). In this study we show that this interaction specifically and timely controls the accumulation of Mcl-1 in the nucleus in response to DNA damage. The IEX-1 protein is rapidly induced...
Alternative Titles
Full title
ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3923326
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3923326
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2010.56
